Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure
Summary: Spliceosome machinery mutations are purina exclusive puppy food common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking.In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified RKI-1447, a Rho-associated protein