TARGETING SRSF2 MUTATIONS IN LEUKEMIA WITH RKI-1447: A STRATEGY TO IMPAIR CELLULAR DIVISION AND NUCLEAR STRUCTURE

Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

Summary: Spliceosome machinery mutations are purina exclusive puppy food common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking.In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified RKI-1447, a Rho-associated protein

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Cyberbullying definitions and measurements in children and adolescents: Summarizing 20 years of global efforts

Despite numerous instruments existing to assist in the measurement of specific cyberbullying behaviors or cyberbullying in general, it is still unclear their purpose, corresponding scenarios, and their effectiveness.This study, therefore, aims to provide a comprehensive review of academic efforts on cyberbullying definitions, measurements, and thei

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Naming Systems during Yoruba Wars: A Sociolinguistic Study

Abstract The various intra-tribal conflagrations which consumed the ceiling fan with 18 inch downrod Yoruba empire of Oyo were fundamentally economic and political.Oyo was renowned as an extraordinary exporter of slaves in the eighteenth century, and also as the seat of government for millions of citizens spanning the whole of South Western Nigeria

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Legal evidence and its role in judicial separation

The Islamic law and the state legislations have given great importance to proof of evidence, because of the great role it plays in the administration of justice and the realization of the truth.The Almighty said: "O David! We did indeed make thee a vicegerent on earth: so judge foerster dermatome map thou between men in truth (and justice): Nor fol

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